分类目录归档：Lumiprobe N-羟基琥珀酰亚胺酯染料 Dye NHS esters

Lumiprobe 磺酸基Cy 5活性脂 Sulfo-Cyanine 5 NHS ester

发表于由

Lumiprobe 磺酸基Cy 5活性脂 Sulfo-Cyanine 5 NHS ester

水溶Cyanine 5琥珀酰亚胺酯（succinimidyl ester（SE）），类似于Cy5® NHS ester，不需要有机溶剂即在水相中即可对各种带氨基分子进行标记。因此该产品尤其适用于对那些在有机溶剂中易变性的蛋白和低溶解度蛋白的标记。
Sulfo-Cyanine 5是Cy5®的衍生物，与很多仪器如读板机（plate readers），显微镜和成像设备等相兼容。是最受欢迎的荧光染料之一。

该染料是高度亲水的、水溶的。

非磺化的衍生物：Cyanine 5 NHS ester。
可以在所有的应用中替代Cy5®，Alexa Fluor 647和DyLight 649。

一般性质
外观：深蓝色粉末
分子量：761.84
分子式：C36H40N3NaO10S2
溶解性：极易溶于水，易溶于DMF和DMSO。
质控：NMR 1H(95%)和13C,TLC,功能性测试
储存条件：储存：收到货后于-20℃避光保存24个月。运输：室温3周，避免长时间暴露于阳光，干燥。
光谱性质
最大激发波长：646
在最大激发波长下的消光系数：271000
最大发射波长：662
荧光量子产率：0.2

General properties

Appearance: dark blue powder
Molecular weight: 761.84
Molecular formula: C36H40N3NaO10S2
Solubility: very good in water, good in DMF and DMSO
Quality control: NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download

Spectral properties

 

Excitation maximum, nm: 646
Extinction coefficient at excitation maximum, Lmol-1cm-1: 271000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.2
CF260: 0.13
CF280: 0.13

 

Lumiprobe Sulfo-Cyanine5.5 NHS ester 磺酸基Cy5.5NHS（水溶性）

发表于由

Lumiprobe Sulfo-Cyanine5.5 NHS ester 磺酸基Cy5.5NHS（水溶性）

上海金畔生物代理Lumiprobe品牌全线产品，欢迎新老客户访问Lumiprobe官网或者咨询我们获取更多相关产品信息。

Sulfo-Cyanine5.5 NHS ester 磺酸基Cy5.5NHS

Sulfo-Cyanine5.5 NHS ester is an amine reactive activated ester of sulfonated far red Cyanine5.5 fluorophore, an analog of Cy5.5®. This is a reagent of choice for the labeling of antibodies, sensitive proteins, and others which require reactions in purely aqueous environment, or without any significant additions of organic co-solvents.

The dye is well suitable for non-invasive in vivo NIR imaging, and for the applications requiring low fluorescent background.

Structure of sulfo-Cyanine5.5 NHS ester

17320 Sulfo-Cyanine 5 .5NHS ester 1 mg
27320 Sulfo-Cyanine 5 .5NHS ester 5 mg
47320 Sulfo-Cyanine 5 .5NHS ester 25 mg
57320 Sulfo-Cyanine 5 .5NHS ester 50 mg
67320 Sulfo-Cyanine 5 .5NHS ester 100 mg

General properties

Appearance: dark blue solid
Mass spec M+ increment: 884.15
Molecular weight: 1114.37
CAS number: N/A
Molecular formula: C44H42N3K3O16S4
Solubility: good in water, DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Spectral properties

Excitation maximum, nm: 675
ε, L⋅mol−1⋅cm−1: 235000
Emission maximum, nm: 694
CF260: 0.09
CF280: 0.11

Product citations

  1. Liu, Q.; Tian, J.; Liu, J.; Zhu, M.; Gao, Z.; Hu, X.; Midgley, A.C.; Wu, J.; Wang, Xi.; Kong, D.; Zhuang, J.; Liu, J.; Yan, X.; Huang, X. Modular Assembly of Tumor-Penetrating and Oligomeric Nanozyme Based on Intrinsically Self-Assembling Protein Nanocages. Advanced Materials, in press. doi: 10.1002/adma.202103128
  2. Lu, Z.; Zhang, Y.; Wang, Y.; Tan, G.-H.; Huang, F.-Y.; Cao, R.; He, N.; Zhang, L. A biotin-avidin-system-based virus-mimicking nanovaccine for tumor immunotherapy. Journal of Controlled Release, 2021, 332, 245–259. doi: 10.1016/j.jconrel.2021.02.029
  3. Shramova, E.; Proshkina, G.; Shipunova, V.; Ryabova, A.; Kamyshinsky, R.; Konevega, A.; Schulga, A.; Konovalova, E.; Telegin, G.; Deyev, S. Dual Targeting of Cancer Cells with DARPin-Based Toxins for Overcoming Tumor Escape. Cancers, 2020, 12(10), 3014. doi: 10.3390/cancers12103014
  4. Peplau, E.; De Rose, F.; Reder, S.; Mittelhaeuser, M.; Scafetta, G.; Schwaiger, M.; Weber, W.A.; Bartolazzi, A.; Skerra, A.; D’Alessandria, C. Development of a chimeric Fab directed against human galectin-3 and validation as an immune-PET tracer for the sensitive in vivo imaging of thyroid cancer. Thyroid, 2020, 30(9), 1314–1326. doi: 10.1089/thy.2019.0670
  5. Sim, T.; Lim, C.; Hoang, N.H.; Shin, Y.; Kim, J.C.; Park, J.Y.; Her, J.; Lee, E.S.; Youn, Y.S.; Oh, K.T. An On-Demand pH-Sensitive Nanocluster for Cancer Treatment by Combining Photothermal Therapy and Chemotherapy. Pharmaceutics, 2020, 12, 839. doi: 10.3390/pharmaceutics12090839
  6. Lix, K.; Krause, K.D.; Kim, H.; Algar, W.R. Investigation of the Energy Transfer Mechanism Between Semiconducting Polymer Dots and Organic Dyes. Journal of Physical Chemistry C, 2020, 124(31), 17387–17400. doi: 10.1021/acs.jpcc.0c04983
  7. Wang, J.; Li, Y.; Li, L.; Yang, J.; Kopeček, J. Exploration and Evaluation of Therapeutic Efficacy of Drug-Free Macromolecular Therapeutics in Collagen-Induced Rheumatoid Arthritis Mouse Model. Macromolecular Bioscience, 2020, 20(5), e1900445. doi: 10.1002/mabi.201900445
  8. Chen, Q.; Gao, M.; Li, Z.; Xiao, Y.; Bai, X.; Boakye-Yiadom, K.O.; Xu, X.; Zhang, X.-Q. Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy. Journal of Controlled Release, 2020, 323, 179–190. doi: 10.1016/j.jconrel.2020.03.044
  9. Taghian, T.; Metelev, V.G.; Zhang, S.; Bogdanov, A.A. Imaging NF-κB activity in a murine model of early stage diabetes. FASEB Journal, 2020, 34(1), 1198–1210. doi: 10.1096/fj.201801147r
  10. Yin, B.; Chan, C.K.W.; Liu, S.; Hong, H.; Wong, S.H.D.; Lee, L.K.C.; Ho, L.W.C.; Zhang, L.; Leung, K.C.-F.; Choi, P.C.-L.; Bian, L.; Tian, X.Y.; Chan, M.N.; Choi, C.H.J. Intrapulmonary Cellular-Level Distribution of Inhaled Nanoparticles with Defined Functional Groups and Its Correlations with Protein Corona and Inflammatory Response. ACS Nano, 2019, 13(12), 14048–14069. doi: 10.1021/acsnano.9b06424
  11. Wu, X.; Zhou, J.; Wang, F.; Meng, X.; Chen, J.; Chang, T.-S.; Lee, M.; Li, G.; Li, X.; Appelman, H.D.; Kuick, R.; Wang, T.D. Detection of colonic neoplasia in vivo using near-infrared-labeled peptide targeting cMet. Scientific Reports, 2019, 9, 17917. doi: 10.1038/s41598-019-54385-7
  12. Khatri, S.; Hansen, J.; Mendes, A.C.; Chronakis, I.S.; Hung, S.-C.; Mellins, E.D.; Astakhova, K. Citrullinated Peptide Epitope Targets Therapeutic Nanoparticles to Human Neutrophils. Bioconjugate Chemistry, 2019, 30(10), 2584–2593. doi: 10.1021/acs.bioconjchem.9b00518
  13. Wang, Y.; Li, K.; Han, S.; Tian, Y.-H.; Hu, P.-C.; Xu, X.-L.; He, Y.-Q.; Pan, W.-T.; Gao, Y.; Zhang, Z.; Zhang, J.-W.; Wei, L. Chlorotoxin targets ERα/VASP signaling pathway to combat breast cancer. Cancer Medicine, 2019, 8(4), 1679–1693. doi: 10.1002/cam4.2019
  14. Ha, S.-W.; Hwang, K.; Jin, J.; Cho, A.-S.; Kim, T.Y.; Hwang, S.I.; Lee, H.J.; Kim, C.-Y. Ultrasound-sensitizing nanoparticle complex for overcoming the blood-brain barrier: an effective drug delivery system. International Journal of Nanomedicine, 2019, 14, 3743–3752. doi: 10.2147/ijn.s193258
  15. Liu, R.; Li, Z.; Marvin, J.S.; Kleinfeld, D. Direct wavefront sensing enables functional imaging of infragranular axons and spines. Nature Methods, 2019, 16, 615–618. doi: 10.1038/s41592-019-0434-7
  16. Guenter, R.E.; Aweda, T.; Carmona Matos, D.M.; Whitt, J.; Chang, A.W.; Cheng, E.Y.; Liu, X.M.; Chen, H.; Lapi, S.E.; Jaskula-Sztul, R. Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors. Cancers, 2019, 11(6), 767. doi: 10.3390/cancers11060767
  17. Kwon, Y.-D.; Oh, J.-M.; La, M.T.; Chung, H.-J.; Lee, S.J.; Chun, S.; Lee, S.-H.; Jeong, B.-H.; Kim, H.-K. Synthesis and Evaluation of Multifunctional Fluorescent Inhibitors with Synergistic Interaction of PSMA and Hypoxia for Prostate Cancer. Bioconjugate Chemistry, 2019, 30(1), 90–100. doi: 10.1021/acs.bioconjchem.8b00767
  18. Liu, Y.; Wang, Z.; Li, X.; Ma, X.; Wang, S.; Kang, F.; Yang, W.; Ma, W.; Wang, J. Near-infrared Fluorescent Peptides with High Tumor Selectivity: Novel Probes for Image-Guided Surgical Resection of Orthotopic Glioma. Molecular Pharmaceutics, 2019, 16(1), 108–117. doi: 10.1021/acs.molpharmaceut.8b00888
  19. Jasinski, D.L.; Yin, H.; Li, Z.; Guo, P. The Hydrophobic Effect from Conjugated Chemicals or Drugs on in Vivo Biodistribution of RNA Nanoparticles. Human Gene Therapy, 2018, 29(1), 77–86. doi: 10.1089/hum.2017.054
  20. Park, S.; Shevlin, E.; Vedvyas, Y.; Zaman, M.; Park, S.; Hsu, Y.-M.S.; Min, I.M.; Jin, M.M. Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity. Scientific Reports, 2017, 7, 14366. doi: 10.1038/s41598-017-14749-3
  21. Zhang, C.; Zhao, X.; Guo, S.; Lin, T.; Guo, H. Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles. International Journal of Nanomedicine, 2017, 12, 1827–1840. doi: 10.2147/ijn.s130539
  22. Duan, X.; Li, H.; Zhou, J.; Zhou, Q.; Oldham, K.R.; Wang, T.D. Visualizing epithelial expression of EGFR in vivo with distal scanning side-viewing confocal endomicroscope. Scientific Reports, 2016, 6, 37315. doi: 10.1038/srep37315
  23. Zhou, Q.; Li, Z.; Zhou, J.; Joshi, B.P.; Li, G.; Duan, X.; Kuick, R.; Owens, S.R.; Wang, T.D. In vivo photoacoustic tomography of EGFR overexpressed in hepatocellular carcinoma mouse xenograft. Photoacoustics, 2016, 4(2), 43–54. doi: 10.1016/j.pacs.2016.04.001
  24. Abolmaali, S.; Tamaddon, A.; Kamali-Sarvestani, E.; Ashraf, M.; Dinarvand, R. Stealth Nanogels of Histinylated Poly Ethyleneimine for Sustained Delivery of Methotrexate in Collagen-Induced Arthritis Model. Pharmaceutical Research, 2015, 32(10), 3309–3323. doi: 10.1007/s11095-015-1708-0

Lumiprobe N-羟基琥珀酰亚胺酯染料 Dye NHS esters

发表于由
Lumiprobe N-羟基琥珀酰亚胺酯染料 Dye NHS esters

Lumiprobe Corporation是美国一家高品质生物技术公司，专业提供分子生物学研究用的活性荧光染料。从2006年开始，公司生产并销售生命科学研究和诊断学应用的优质化学药品。产品主要有：活性染料(Reactive Dye)和SYBR Green I 染料，用于寡核苷酸合成的亚磷酰胺，点击化学用染料和其它试剂。 产品主要应用：点击化学(Click Chemistry)、蛋白质组学研究中的双向荧光差异凝胶电泳(2D DIGE)和实时荧光定量PCR(Realtime PCR)。

 Lumiprobe N-羟基琥珀酰亚胺酯染料 Dye NHS esters
Cy3-N-羟基琥珀酰亚胺酯  Cyanine3 NHS ester

Amine-reactive Cyanine3 dye NHS ester.

Cyanine3 NHS ester
Cy3.5-N-羟基琥珀酰亚胺酯 Cyanine3.5 NHS ester

Cyanine3.5 dye NHS ester derivative.

Cyanine3.5 NHS ester
Cy5-N-羟基琥珀酰亚胺酯 Cyanine5 NHS ester

Amine-reactive Cyanine5 activated ester for the labeling of proteins, peptides, and other molecules.

Cyanine5 NHS ester
Cy5.5-N-羟基琥珀酰亚胺酯 Cyanine5.5 NHS ester

Cyanine5.5 NHS is far-red / near-infrared amine-reactive dye.

Cyanine5.5 NHS ester
Cy7-N-羟基琥珀酰亚胺酯 Cyanine7 NHS ester

Amine reactive NHS ester of near infrared dye Cyanine7.

Cyanine7 NHS ester
Cy7.5-N-羟基琥珀酰亚胺酯 Cyanine7.5 NHS ester

Amine reactive NHS ester of NIR fluorescent dye Cyanine7.5.

Cyanine7.5 NHS ester
6-ROX-N-羟基琥珀酰亚胺酯 ROX NHS ester, pure 6- isomer

Pure isomer 6-ROX NHS ester for amine labeling.

ROX NHS ester, pure 6- isomer
磺酸基-Cy3-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine3 NHS ester

Water soluble sulfo-Cyanine3 SE activated ester for amino-biomolecule labeling.

Sulfo-Cyanine3 NHS ester
磺酸基-Cy5-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine5 NHS ester

Water-soluble Cyanine 5 succinimide ester.

Sulfo-Cyanine5 NHS ester
磺酸基-Cy7-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine7 NHS ester

Sulfo-Cyanine7 NHS ester is a water soluble, near infrared, amine-reactive dye.

Sulfo-Cyanine7 NHS ester
BDP FL N-羟基琥珀酰亚胺酯 BDP FL NHS ester

Amino-reactive BDP FL, a very bright and photostable dye for fluorescein channel.

BDP FL NHS ester

Lumiprobe N-羟基琥珀酰亚胺酯染料 Dye NHS esters

货号

中文名

产品描述
11420 BDP FL N-羟基琥珀酰亚胺酯 BDP FL NHS ester, 1 mg
21420 BDP FL N-羟基琥珀酰亚胺酯 BDP FL NHS ester, 5 mg
41420 BDP FL N-羟基琥珀酰亚胺酯 BDP FL NHS ester, 25 mg
51420 BDP FL N-羟基琥珀酰亚胺酯 BDP FL NHS ester, 50 mg
61420 BDP FL N-羟基琥珀酰亚胺酯 BDP FL NHS ester, 100 mg
11020 Cy3-N-羟基琥珀酰亚胺酯 Cyanine3 NHS ester, 1 mg
21020 Cy3-N-羟基琥珀酰亚胺酯 Cyanine3 NHS ester, 5 mg
41020 Cy3-N-羟基琥珀酰亚胺酯 Cyanine3 NHS ester, 25 mg
51020 Cy3-N-羟基琥珀酰亚胺酯 Cyanine3 NHS ester, 50 mg
61020 Cy3-N-羟基琥珀酰亚胺酯 Cyanine3 NHS ester, 100 mg
12020 Cy3.5-N-羟基琥珀酰亚胺酯 Cyanine3.5 NHS ester, 1 mg
22020 Cy3.5-N-羟基琥珀酰亚胺酯 Cyanine3.5 NHS ester, 5 mg
42020 Cy3.5-N-羟基琥珀酰亚胺酯 Cyanine3.5 NHS ester, 25 mg
52020 Cy3.5-N-羟基琥珀酰亚胺酯 Cyanine3.5 NHS ester, 50 mg
62020 Cy3.5-N-羟基琥珀酰亚胺酯 Cyanine3.5 NHS ester, 100 mg
13020 Cy5-N-羟基琥珀酰亚胺酯 Cyanine5 NHS ester, 1 mg
23020 Cy5-N-羟基琥珀酰亚胺酯 Cyanine5 NHS ester, 5 mg
43020 Cy5-N-羟基琥珀酰亚胺酯 Cyanine5 NHS ester, 25 mg
53020 Cy5-N-羟基琥珀酰亚胺酯 Cyanine5 NHS ester, 50 mg
63020 Cy5-N-羟基琥珀酰亚胺酯 Cyanine5 NHS ester, 100 mg
17020 Cy5.5-N-羟基琥珀酰亚胺酯 Cyanine5.5 NHS ester, 1 mg
27020 Cy5.5-N-羟基琥珀酰亚胺酯 Cyanine5.5 NHS ester, 5 mg
47020 Cy5.5-N-羟基琥珀酰亚胺酯 Cyanine5.5 NHS ester, 25 mg
57020 Cy5.5-N-羟基琥珀酰亚胺酯 Cyanine5.5 NHS ester, 50 mg
67020 Cy5.5-N-羟基琥珀酰亚胺酯 Cyanine5.5 NHS ester, 100 mg
15020 Cy7-N-羟基琥珀酰亚胺酯 Cyanine7 NHS ester, 1 mg
25020 Cy7-N-羟基琥珀酰亚胺酯 Cyanine7 NHS ester, 5 mg
45020 Cy7-N-羟基琥珀酰亚胺酯 Cyanine7 NHS ester, 25 mg
55020 Cy7-N-羟基琥珀酰亚胺酯 Cyanine7 NHS ester, 50 mg
65020 Cy7-N-羟基琥珀酰亚胺酯 Cyanine7 NHS ester, 100 mg
16020 Cy7.5-N-羟基琥珀酰亚胺酯 Cyanine7.5 NHS ester, 1 mg
26020 Cy7.5-N-羟基琥珀酰亚胺酯 Cyanine7.5 NHS ester, 5 mg
46020 Cy7.5-N-羟基琥珀酰亚胺酯 Cyanine7.5 NHS ester, 25 mg
56020 Cy7.5-N-羟基琥珀酰亚胺酯 Cyanine7.5 NHS ester, 50 mg
66020 Cy7.5-N-羟基琥珀酰亚胺酯 Cyanine7.5 NHS ester, 100 mg
12220 6-ROX-N-羟基琥珀酰亚胺酯 ROX NHS ester, pure 6- isomer, 1 mg
22220 6-ROX-N-羟基琥珀酰亚胺酯 ROX NHS ester, pure 6- isomer, 5 mg
42220 6-ROX-N-羟基琥珀酰亚胺酯 ROX NHS ester, pure 6- isomer, 25 mg
52220 6-ROX-N-羟基琥珀酰亚胺酯 ROX NHS ester, pure 6- isomer, 50 mg
62220 6-ROX-N-羟基琥珀酰亚胺酯 ROX NHS ester, pure 6- isomer, 100 mg
11320 磺酸基-Cy3-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine3 NHS ester, 1 mg
21320 磺酸基-Cy3-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine3 NHS ester, 5 mg
41320 磺酸基-Cy3-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine3 NHS ester, 25 mg
51320 磺酸基-Cy3-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine3 NHS ester, 50 mg
61320 磺酸基-Cy3-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine3 NHS ester, 100 mg
13320 磺酸基-Cy5-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine5 NHS ester, 1 mg
23320 磺酸基-Cy5-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine5 NHS ester, 5 mg
43320 磺酸基-Cy5-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine5 NHS ester, 25 mg
53320 磺酸基-Cy5-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine5 NHS ester, 50 mg
63320 磺酸基-Cy5-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine5 NHS ester, 100 mg
15320 磺酸基-Cy7-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine7 NHS ester, 1 mg
25320 磺酸基-Cy7-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine7 NHS ester, 5 mg
45320 磺酸基-Cy7-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine7 NHS ester, 25 mg
55320 磺酸基-Cy7-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine7 NHS ester, 50 mg
65320 磺酸基-Cy7-N-羟基琥珀酰亚胺酯 Sulfo-Cyanine7 NHS ester, 100 mg

Lumiprobe cy7.5马来酰亚胺|Cyanine7.5 maleimide

发表于由

Lumiprobe cy7.5马来酰亚胺|Cyanine7.5 maleimide

  • 英文名：Cyanine7.5 maleimide
  • 级别：NMR 1H (95%) and 13C， TLC， functional testing
  • 分子式：C51H55ClN4O3
  • 分子量：807.46
  • 品牌：lumiprobe
  • 外观：green powder
订购货号 产品名称及规格
16080 Cyanine7.5 maleimide, 1 mg
26080 Cyanine7.5 maleimide, 5 mg
46080 Cyanine7.5 maleimide, 25 mg
56080 Cyanine7.5 maleimide, 50 mg
66080 Cyanine7.5 maleimide, 100 mg

硫醇活性染料、近红外Cyanine7.5，用于标记蛋白的巯基基团，是Cy7.5® maleimide的类似物。
大多数蛋白含有巯基基团，可以选择性的标记马来酰亚胺。该试剂可以使这些蛋白连接上近红外荧光团。然后，该复合物可以用于非入侵性的活体成像，来研究组织和生物体内的蛋白分布。

推荐手册：

蛋白与其他硫醇分子的马来酰亚胺标记

Cy® is a trademark of GE Healthcare.

General properties

Appearance: >green powder
Molecular weight: >807.46
Molecular formula: C51H55ClN4O3
Solubility: >soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: >NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download

Spectral properties

Excitation maximum, nm: 788
Extinction coefficient at excitation maximum, Lmol-1cm-1: 223000
Emission maximum, nm: 808

Lumiprobe Cy7.5-N-羟基琥珀酰亚胺酯

发表于由

Lumiprobe Cy7.5-N-羟基琥珀酰亚胺酯

上海金畔生物代理Lumiprobe品牌产品，欢迎新老客户访问Lumiprobe官网或者咨询我们获取更多相关产品信息。

订购货号 产品名称及规格
16020 Cyanine7.5 NHS ester, 1 mg
26020 Cyanine7.5 NHS ester, 5 mg
46020 Cyanine7.5 NHS ester, 25 mg
56020 Cyanine7.5 NHS ester, 50 mg
66020 Cyanine7.5 NHS ester, 100 mg

Cyanine7.5是一种近红外荧光染料，具有很长的发射光谱，是此类荧光衍生而来的活性胺产品。近红外照射很容易穿透组织因此常应用于体内成像领域。该产品可以用于标记含有氨基的小分子物质，比如蛋白和多肽，通过近红外光谱成像技术（NIR imaging）来示踪他们在有机体内的分布。中心聚亚甲基基团的增强的稳定性使得量子产率较其母结构Cy7.5® NHS提高20%。

推荐手册氨基分子的NHS酯标记

General properties

Appearance: green powder
Mass spec M+ increment: 630.4
Molecular weight: 833.76
CAS number: 1469541-54-5 (without anion), 1469278-04-3 (chloride)
Molecular formula: C49H52N3BF4O4
IUPAC name: 1H-​Benz[e]​indolium, 2-​[2-​[3-​[2-​(1,​3-​dihydro-​1,​1,​3-​trimethyl-​2H-​benz[e]​indol-​2-​ylidene)​ethylidene]​-​1-​cyclohexen-​1-​yl]​ethenyl]​-​3-​[6-​[(2,​5-​dioxo-​1-​pyrrolidinyl)​oxy]​-​6-​oxohexyl]​-​1,​1-​dimethyl-
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

 

Spectral properties

Excitation maximum, nm: 788
Extinction coefficient at excitation maximum, Lmol-1cm-1: 223000
Emission maximum, nm: 808

Product citations

  • Zhang, Z.; Cai, H.; Liu, Z.; Yao, P. Effective Enhancement of Hypoglycemic Effect of Insulin by Liver-targeted Nanoparticles Containing Cholic Acid-modified Chitosan Derivative. Molecular Pharmaceutics, in press. doi:10.1021/acs.molpharmaceut.6b00188
  • Dou, Y.; Guo, J.; Chen, Y.; Han, S.; Xu, X.; Shi, Q.; Jia, Y.; Liu, Y.; Deng, Y.; Wang, R.; Li, X.; Zhang, J. Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice. Journal of Controlled Release, 2016, 235, 48–62. doi: 10.1016/j.jconrel.2016.05.049
  • Markovic, S.; Belz, J.; Kumar, R.; Cormack, R.A.; Sridhar, S.; Niedre, M. Near-infrared fluorescence imaging platform for quantifying in vivo nanoparticle diffusion from drug loaded implants. International Journal of Nanomedicine, 2016, 11, 1213–1223. doi: 10.2147/IJN.S93324
  • Han, F.Y.; Thurecht, K.J.; Lam, A.-L.; Whittaker, A.K.; Smith, M.T. Novel Polymeric Bioerodable Microparticles for Prolonged-Release Intrathecal Delivery of Analgesic Agents for Relief of Intractable Cancer-Related Pain. Journal of Pharmaceutical Sciences, 2015, 104(7), 2334–2344. doi: 10.1002/jps.24497
  • Duong, H.T.T.; Dong, Z.; Su, L; Boyer, C.; George, J.; Davis, T.P.; Wang, J. The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension. Small, 2015, 11(19), 2291–2304.201402870
  • Chen, K.; Xu, X.; Guo, J.W.; Zhang, X.; Han, S.; Wang, R.; Li, X.; Zhang, J. Enhanced Intracellular Delivery and Tissue Retention of Nanoparticles by Mussel-Inspired Surface Chemistry. Biomacromolecules, 2015, 16(11), 3574–3583. doi:10.1021/acs.biomac.5b01056
  • Lin, Y.-A.; Cheetham, A.G.; Zhang, P.; Ou, Y.-C.; Li, Y.; Liu, G.; Hermida Merino, D.; Hamley, I.W.; Cui, H. Multi-Walled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles. ACS Nano, 2014, 8(12), 12690-12700. doi: 10.1021/nn505688b
  • Graen, T.M.D.; Hoefling, M.; Grubmüller, H. AMBER-DYES: Characterization of Charge Fluctuations and Force Field Parameterization of Fluorescent Dyes for Molecular Dynamics Simulations. Journal of Chemical Theory and Computation, 2014, 10(12), 5505-5512. doi: 10.1021/ct500869p
  • Lu, H.D.; Soranno, D.E.; Rodell, C.B.; Kim, I.L.; Burdick, J.A. Secondary Photocrosslinking of Injectable Shear-Thinning Dock-and-Lock Hydrogels. Advanced Healthcare Materials, 2013, 2(7), 1028-1036. doi: 10.1002/adhm.201200343
  • Yang, H.; Mao, H.; Wan, Z.; Zhu, A.; Guo, M.; Li, Y.; Li, X.; Wan, J.; Yang, X.; Shuai, X. et al. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials, 2013, 34(36), 9124-9133. doi: 10.1016/j.biomaterials.2013.08.022

Lumiprobe 磺酸基CY5 NHS染料 Sulfo-Cyanine5 bis-NHS ester

发表于由

Lumiprobe 磺酸基CY5 NHS染料 Sulfo-Cyanine5 bis-NHS ester

上海金畔生物代理Lumiprobe品牌产品，欢迎新老客户访问Lumiprobe官网或者咨询我们获取更多相关产品信息。

free express shipping.

Sulfo-Cyanine5 bis-NHS ester is a water soluble bifunctional dye possessing two NHS ester functions. It is an analog of Cy5® bis-NHS ester.

The dye is useful for the cross-conjugation of amines, and for other advanced labeling applications.

Sulfo-Cyanine5 bis-NHS ester, 633D0

Structure of Sulfo-Cyanine5 bis-NHS ester

Cat. # Quantity Lead time
133D0 1 mg in stock
233D0 5 mg in stock
433D0 25 mg in stock
533D0 50 mg in stock
633D0 100 mg in stock

General properties

Appearance: dark blue powder
Molecular weight: 975.14
Molecular formula: C45H51KN4O14S2
Solubility: good in DMF, DMSO, water
Quality control: NMR 1H, HPLC-MS (895%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Spectral properties

Excitation maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 271000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.28
CF260: 0.04
CF280: 0.04